Myositis Insights

Telugu Actress Kapilakshi Malhotra Diagnosed with Myositis

Telugu actress Kapilakshi Malhotra has been diagnosed with myositis, an autoimmune condition that affects muscle tissues. The article provides an overview of myositis, its symptoms, and how it impacts the body.

Study Reveals Key Factors in Muscle Weakness Due to Myositis

Researchers have identified key factors contributing to muscle weakness in myositis, including inflammation and immune system dysregulation. Understanding these factors could lead to new treatments for managing muscle weakness in people with myositis.

Research Awards Offer New Hope for Rare Disease Patients

New research awards are providing hope for individuals with myositis and other rare diseases by funding innovative studies and treatments. These grants aim to advance understanding and develop effective therapies for these conditions.

Recent studies have highlighted the complexities and challenges in managing myositis. Deveci et al. (2025) reported on two cancer patients who developed myositis with symptoms resembling myasthenia gravis after treatment with pembrolizumab, an immune checkpoint inhibitor. Despite aggressive treatment, both patients succumbed to complications, highlighting the severity of this immune-related adverse event.

In another study, Ikenaga et al. (2025) discovered that in inclusion body myositis (IBM), a loss of TDP-43 splicing repression leads to the production of cryptic peptides, which could serve as potential biomarkers for the disease. This finding suggests a new avenue for therapeutic strategies aimed at restoring TDP-43 function.

Furthermore, Potter et al. (2025) investigated immune-mediated myositis (IMM) following gene therapy with delandistrogene moxeparvovec in patients with Duchenne muscular dystrophy (DMD). They found that T cell responses to specific micro-dystrophin peptides were implicated in IMM, particularly in patients with certain genetic deletions, indicating a need for careful patient selection and monitoring in gene therapy treatments. These studies collectively underscore the importance of early detection and tailored management in myositis to improve patient outcomes.